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Mental Health

  NEW  The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model.  Read about an interesting new hypothesis about the relationship between early life trauma and the development of psychotic neuropsychiatric symptoms later in life.  Dr. Read, a psychologist in New Zealand generously included Dr. Perry as a co-author in this important review.  Dr. Read's seminal clinical and research efforts are highlighted in this recent article.  (Official citation: Read, J., Perry, B.D., Moskowitz, A. & Connolly, J.  The contribution of early traumatic events to schizophrenia in some patients: a traumagenic neurodevelopmental model.  Psychiatry 64 (4)  319-345, 2001)   PDF Version

Violence and Childhood:  How Persisting Fear Can Alter the Developing Child’s Brain
NEW Click here for new PDF version of this article.

Neurobiological Sequelae of Childhood Trauma: Post-traumatic Stress Disorders in Children

Children in Psychologically-Destructive Settings: Working with the Branch Davidians

Adrenergic Receptor Regulation in Postraumatic Stress Disorders

The Post-Traumatic Response in Children and Adolescents

Pediatrics

Post-traumatic Stress Disorders in Children and Adolescents

Neuropsychological Impact of Facial Deformities in Children:
Neurodevelopmental Role of the Face in Communication and Bonding

Instructor Resource for Teaching Prehospital Pediatrics
EMT Training Manual: Role of the EMS Provider in Crisis Intervention:
Neurophysiological Aspects of Acute Trauma in Children.

Basic and Developmental Neurosciences

             Research in basic neurosciences and developmental neurobiology has been the basis of the current ChildTrauma Academy preclinical research and practice.  This section will highlight some of the basis and pre-clinical neuroscience work that helped drive some of our current interests.  Most of the highlighted articles are from Dr. Perry’s work; over time, however, we will link to and comment on recent studies in basic neuroscience which continue to inform our evolving work.

NEW Effects of chronic sleep deprivation on central cholinergic receptors in rat brain

Sleep deprivation impacts the patterns of neurochemical activity in the brain.  This study tried to look at some of the important biochemical systems that might be impacted by this deprivation.  (Official citation: Tsai, L.L., Bergmann, B.M., Perry, B.D. & Rechtschaffen, A.  Effects of chronic sleep deprivation on central cholinergic receptors in rat brain   Brain Research, 642: 95-103, 1994)  PDF File

  NEW Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain

This key finding in this article is that brief patterns of activation of selected dopaminergic systems in the brain can result in enduring changes in important neurochemical systems in the brain.  Similar patterns of activating the stress response can cause similar altered neurochemistry.  (Official citation:  Kleven, M., Perry, B.D., Woolverton, W. & Seiden, L.  Effects of repeated injections of cocaine on D1 and D2 dopamine receptors in rat brain.  Brain Research, 532: 265-270, 1990)  PDF File

  NEW Immortalized murine striatal neuronal cell lines expressing dopamine receptors and cholinergic properties

This paper describes a set of studies in which a cellular model for immature corpus striatum cells is created. This immortalized cell line has been helpful in studying the developmental properties of important neurochemical systems in the brain. (Official citation: Wainwright, M.S., Perry, B.D., Won, L.A., O'Malley, K.L., Wang, W-Y & Heller, A. Immortalization of murine striatal neurons by somatic cell fusion with the N18TG2 neuroblastoma: Characterization of cell lines expressing a variety of dopamine receptors and cholinergic markers. J Neuroscience, 15 (1):676-688, 1995)  PDF File

Prenatal exposure to drugs of abuse in humans: Effects on placental neurotransmitter receptors  

This article is the one of first studies that demonstrated neurochemical changes in the human fetus/child following pre-natal exposure to various drugs of abuse.  Of interest is that this study also illustrated the impact of prolonged stress response on neurochemical markers in the fetus/infant.  (Official citation:  Perry, B.D., Pesavento, D.J., Kussie, P.H., U'Prichard, D.C. & Schnoll, S.H.  Prenatal exposure to drugs of abuse in humans: Effects on placental neurotransmitter receptors.  Neurobehavioral Toxicology and Teratology, 6, 295-301, 1984)   PDF File

  Placental and blood element neurotransmitter receptor regulation in humans: potential models for studying neurochemical mechanisms underlying behavioral teratology.   

In this monograph the concept of chronic activation of the stress-response neurobiology in the brain causing alterations that lead to PTSD is first suggested.  A similar mechanism for abnormal neurobiological signals during neglect is suggested as well.  (Official citation: Perry, B.D.  Placental and blood element neurotransmitter receptor dysregulation:  A model for examining mechanisms of neurochemical teratology in humans.  Chapter 13. In: Neurochemistry of Functional Neuroteratology, Progress in Brain Research. Vol. 73  (GJ Boer, MGP Feenstra, M Mirmiran et al. Eds.).  Elsevier Press, Amsterdam, 189-206, 1988)  PDF File